Proton Beam Therapy in Pediatrics : A Review

Main Article Content

Putri Pradita Nuramalia
Syarifah Miftahul El Jannah

Abstract

Pediatric cancer, including leukemia and brain tumors, is increasingly diagnosed, with about 400,000 cases annually. Conventional radiation therapy, while effective, can lead to long-term side effects, including secondary cancers. This review paper aims at discussing what proton beam therapy (PBT) has to offer for children suffering from cancer looking at its advantages and disadvantages. Literature on PBT and conventional radiotherapy was reviewed to compare treatment efficacy and side effects. PBT allows precise tumor targeting while minimizing damage to surrounding healthy tissue, resulting in fewer long-term effects. Studies show higher conformity indexes for PBT, reducing risks of growth disorders and cognitive impairment. Proton beam therapy shows significant promise for improving pediatric cancer treatment outcomes and quality of life. However, high costs and limited long-term data hinder its broader adoption, necessitating further research to optimize its use.

Article Details

How to Cite
1.
Nuramalia P, El Jannah S. Proton Beam Therapy in Pediatrics : A Review. SANITAS [Internet]. 21Apr.2025 [cited 24Apr.2025];15(2):161-9. Available from: https://sanitas.e-journal.id/index.php/SANITAS/article/view/538
Section
Radiation Therapy

References

Saini A, Kumar M, Bhatt S, Saini V. Cancer Causes and Treatment. Int J Pharm Sci Res. 2020;11(7):3121–34.

Tewari M. Cancer and Its Treatment: an Overview. Int J Adv Res (Indore) [Internet]. 2022;10(03):950–6. Available from: http://dx.doi.org/10.21474/IJAR01/14476

Wold Health Organization [Internet]. 2021 [cited 2024 May 25]. Childhood cancer. Available from: https://www.who.int/news-room/fact-sheets/detail/cancer-in-children

Lam CG, Howard SC, Bouffet E, Pritchard-Jones K. Science and health for all children with cancer. Science (1979). 2019;360(9):245–51.

Hariyanto AD, Wijaya HM, Anton J, Yanuarta SE, Octavianus S, Handoko H, et al. The Role of Radiotherapy towards Pediatric Cancer. Radioterapi & Onkologi Indonesia. 2020;11(2):57–65.

Ndlovu N. Radiotherapy treatment in cancer control and its important role in Africa. Ecancermedicalscience. 2019;13:1–7.

Shen CJ, Terezakis SA. The Evolving Role of Radiotherapy for Pediatric Cancers With Advancements in Molecular Tumor Characterization and Targeted Therapies. Front Oncol. 2021;11.

Mizumoto M, Fuji H, Miyachi M, Soejima T, Yamamoto T, Aibe N, et al. Proton beam therapy for children and adolescents and young adults (AYAs): JASTRO and JSPHO Guidelines. Cancer Treat Rev. 2021;98:1–10.

Berrington de González A, Gibson TM, Lee C, Albert PS, Griffin KT, Kitahara CM, et al. The Pediatric Proton and Photon Therapy Comparison Cohort: Study Design for a Multicenter Retrospective Cohort to Investigate Subsequent Cancers After Pediatric Radiation Therapy. Adv Radiat Oncol. 2023 Nov 1;8(6).

Hu M, Jiang L, Cui X, Zhang J, Yu J. Proton beam therapy for cancer in the era of precision medicine. J Hematol Oncol. 2018;11(1):1–16.

Kattner P, Strobel H, Khoshnevis N, Grunert M, Bartholomae S, Pruss M, et al. Compare and contrast: pediatric cancer versus adult malignancies. Cancer and Metastasis Reviews. 2019;38(4):673–82.

Bosse KR, Majzner RG, Mackall CL, Maris JM. Immune-Based Approaches for the Treatment of Pediatric Malignancies. Annu Rev Cancer Biol. 2020;4:353–70.

Agarwal S. Pediatric Cancers: Insights and Novel Therapeutic Approaches. Cancers (Basel). 2023;15(14):20–3.

Radhakrishnan V. Cancer in children: The tip of the iceberg. Indian J Cancer [Internet]. 2021; Available from: www.indianjcancer.com

Erdmann F, Frederiksen LE, Bonaventure A, Mader L, Hasle H, Robison LL, et al. Childhood cancer: Survival, treatment modalities, late effects and improvements over time. Cancer Epidemiol [Internet]. 2021;71. Available from: https://doi.org/10.1016/j.canep.2020.101733

Rath AK, Sahoo N. Particle radiotherapy: Emerging technology for treatment of cancer. Particle Radiotherapy: Emerging Technology for Treatment of Cancer. New Delhi: Springer; 2016. 1–194 p.

Liu H, Chang JY. Proton therapy in clinical practice. Chin J Cancer. 2011;30(5):315–26.

Mohan R. A review of proton therapy – Current status and future directions. Precis Radiat Oncol. 2022;6(2):164–76.

Cotter SE, Mcbride SM, Yock TI. Proton radiotherapy for solid tumors of childhood. Technol Cancer Res Treat. 2012;11(3):267–78.

Beni MS, Krstic D, Nikezic D, Yu KN. A comparative study on dispersed doses during photon and proton radiation therapy in pediatric applications. PLoS One. 2021 Mar 1;16(3 March).

Lautenschlaeger S, Iancu G, Flatten V, Baumann K, Thiemer M, Dumke C, et al. Advantage of proton-radiotherapy for pediatric patients and adolescents with Hodgkin’s disease. Radiation Oncology. 2019 Sep 2;14(1).

Press RH, Mehta MP. Proton Therapy: Current Status and Controversies. JCO Oncol Pract. 2024 Jun;20(6):747–9.

Angel Calvo Manuel F, Panizo E, M. Martin S, Serrano J, Cambeiro M, Azcona D, et al. Proton Cancer Therapy: Synchrotron-Based Clinical Experiences 2020 Update. In: Proton Therapy - Current Status and Future Directions [Internet]. IntechOpen; 2021 [cited 2024 Sep 9]. Available from: http://dx.doi.org/10.5772/intechopen.94937