Main Article Content
Paracetamol formulated in solution, can be hydrolyzed to p-aminophenol, then can be broken down again into quinone-imin. The decomposition rate of paracetamol increases when the temperature is raised and if it is exposed to light directly. The habit of people in storing drugs after the packaging is opened and will be used again raises concerns about the quality of the drugs contained in the drug. The purpose of this study was to determine the level of paracetamol stored at room temperature and chiller temperature using the High Performance Liquid Chromatography (HPLC) method. The study was conducted by testing the levels of paracetamol syrup on the first day and after being stored for three days. Samples were divided into two groups of storage temperatures, room temperature and chiller temperature. The HPLC system used is the L1 column, the mobile phase water-methanol P mixture (3: 1), the flow rate 1.5. The average paracetamol levels at day 1 storage at room temperature and chiller temperature were 104.61% and 102.38%. The average paracetamol levels at day 3 storage at room temperature and chiller temperature were 102, 44% and 98.81%. Storage of paracetamol syrup at the chiller temperature produces smaller levels than at room temperature. Storage for three days shows a significant decrease in levels both at room temperature or chiller temperature (pvalue <0.05).
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Rosalina V. Analisis Kadar Sedian Parasetamol Syrup Pada Anak Terhadap Lama Penyimpanan Dan Suhu Penyimpanan. Parapemikir J Ilm Farm. 2018
Koshy KT, Lach JL. Stability of aqueous solutions of N‐Acetyl‐p‐aminophenol. J Pharm Sci. 1961;50(2):113–8.
Fairbrother JE. Acetaminophen. Anal Profiles Drug Subst. 1974
Dahn IJR, Van T, Westminster N. Stable liquid paracetamol compositions, and method for preparing same. 1990
Connors K, Amidon G, Stella V. Chemical stability of pharmaceuticals: a handbook for pharmacists. 1986
Zulkarnain I. Stabilitas Kimia Dan Usia Simpan Sirup Parasetamol Pada Berbagai Suhu Penyimpanan. As-Syifa. 2014
Awalina LK. Uji Stabilitas Dipercepat Sediaan Parasetamol Sirup Dalam Kemasan Botol Polietilen Tereftalat Dengan Metode Spektrofotometri Uv- Vis. Al-ghifari Bandung; 2017.